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KMID : 0882420080750000870
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Korean Journal of Medicine
2008 Volume.75 No. 0 p.870 ~ p.876
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A case of anterior pituitary hormone deficiency caused by a relapsed malignant lymphoma
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Lim Yun-Hyuk
Nho Hye-Jung
Park Jong-Bin
Shim Hyeok
Park Byoung-Hyun
Park Moo-Rim
Cho Chung-Gu
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Abstract
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Malignant lymphomas involving the pituitary gland are rare. We report a case of relapsed large B-cell non-Hodgkin’s lymphoma affecting the anterior pituitary gland. The patient was a 47-year-old man who presented with headache, weakness, and tingling sensation involving both lower extremities. He had achieved the complete remission of lymphoma 5 months earlier. The thyroid stimulating hormone and free thyroxine levels were decreased at the time of admission. Magnetic resonance imaging showed secondary lymphoma involving the pituitary fossa, cavernous sinus, pineal gland, and cranial nerves. The anterior pituitary hormone levels were low and lymphoma cells were detected in the cerebrospinal fluid. The patient was treated with hydrocortisone, levothyroxine, high-dose methotrexate, and intrathecal methotrexate, and achieved complete remission of the pituitary mass. Pituitary function recovered after remission of the pituitary mass. (Korean J Med 75:S870-S876, 2008)
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KEYWORD
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Malignant lymphoma, Anterior pituitary, Hypopituitarism
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